Call Us @ 0172 - 4680800 | info@indswift.com | NSE - BSE
Brain Connections in Schizophrenia
 
Executive cognitive functions abilities that include working memory and underlie mental control and self-regulation are impaired in schizophrenia. Current pharmacological and behavioral interventions have only modest pro-cognitive effects.

In studies of individuals with schizophrenia and healthy participants, Neil Woodward, PhD, and colleagues tested executive functions and used imaging (diffusion-weighted MRI) to quantify connections between brain regions that support executive functions.

They report in the March 15 issue of Biological Psychiatry that connectivity between the prefrontal cortex and the thalamus is reduced in schizophrenia. The reduced connectivity correlated with impaired working memory but not with other executive functions (cognitive flexibility and inhibition). They also found increased connectivity between the thalamus and the somatosensory and occipital cortices in schizophrenia.
The findings are consistent with other studies that implicate disrupted prefrontal cortex-thalamic function in the pathophysiology of schizophrenia, and they suggest that the connection between these brain regions may be an important target for pro-cognitive interventions.

(Neuroscience.com)
 
Other Related News:
2019 FDA Approved Drugs
FDA announces another carcinogenic impurity in ARB blood pressure drugs
Researchers identify common genetic signature among three rare skin diseases
Health ministry to amend Section 71 of D&C Rules to make Pharm D professionals eligible to supervise drug manufacturing
3rd International Diabetes Summit to be held in Pune from March 8-10, 2019
Health ministry to roll out common IT platform for management of sales and manufacturing licenses of drugs
Cosmetics licences may come with product composition details to enhance safety; new clause proposed in Cosmetics Rules 2018
T-cell specificity found to play a role in attacks on myelin versus β-synuclein in MS
Plazomicin noninferior to meropenem for complicated UTI
New molecules reverse memory loss linked to depression, aging